INTERNAL TRACTS OF TELOMERIC DNA ACT AS SILENCERS IN SACCHAROMYCES-CEREVISIAE

被引：74

作者：

STAVENHAGEN, JB

ZAKIAN, VA

机构：

[1] Fred Hutchinson Cancer Res. Center, Seattle

来源：

GENES & DEVELOPMENT | 1994年 / 8卷 / 12期

关键词：

TELOMERES; YEAST; POSITION EFFECT; SILENCERS;

D O I：

10.1101/gad.8.12.1411

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Telomeric position effect (TPE) refers to the ability of telomeres to repress the transcription of genes in their vicinity. Internal stretches of C(1-3)A DNA, the sequence found at Saccharomyces telomeres, also repressed transcription of nearby genes. This repression, hereafter called C(1-3)A-based silencing, was observed at several chromosomal loci, including on a circular chromosome. The magnitude of C(1-3)A-based silencing was increased by both proximity to a telomere and increased length of the C(1-3)A tracts. C(1-3)A-based silencing was affected by many of the same genes and conditions that influence TPE and acted in an orientation-independent manner. Thus, in yeast, an expanded array of a simple repetitive DNA, C(1-3)A, is sufficient to promote the assembly of a transcriptionally silent chromosomal domain.

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页码：1411 / 1422

页数：12

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