INTERFERON-ALPHA INHIBITS MURINE MACROPHAGE TRANSFORMING GROWTH-FACTOR-BETA MESSENGER-RNA EXPRESSION

被引：18

作者：

DHANANI, S ^{[1
]}

HUANG, M ^{[1
]}

WANG, JY ^{[1
]}

DUBINETT, SM ^{[1
]}

机构：

[1] W LOS ANGELES VET AFFAIRS MED CTR, LOS ANGELES, CA 90073 USA

来源：

INFLAMMATION | 1994年 / 18卷 / 03期

关键词：

D O I：

10.1007/BF01534271

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Transforming growth factor-beta (TGF-beta), a multifunctional polypeptide is produced by a wide variety of cells and regulates a broad array of physiological and pathological functions. TGF-beta appears to play a central role in pulmonary fibrosis and may contribute to tumor-associated immunosuppression. Alveolar macrophages are a rich source of TGF-beta and are intimately involved in lung inflammation. We therefore chose to study TGF-beta regulation in murine alveolar macrophages as well as an immortalized peritoned macrophage cell line (IC-21). Murine macrophages were incubated with cytokines to evaluate their role in regulating TGF-beta mRNA expression. We conclude that IFN-alpha downregulates TGF-beta mRNA expression in murine macrophages.

引用

页码：301 / 309

页数：9

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