ISOLATION OF A HUMAN CEREBRAL IMIDAZOLINE-SPECIFIC BINDING-PROTEIN

被引：26

作者：

GRENEY, H ^{[1
]}

BENNAI, F ^{[1
]}

MOLINES, A ^{[1
]}

BELCOURT, A ^{[1
]}

DONTENWILL, M ^{[1
]}

BOUSQUET, P ^{[1
]}

机构：

[1] UNIV STRASBOURG 1,FAC MED,PHARMACOL CARDIOVASC & RENALE LAB,CNRS,URA 589,F-67000 STRASBOURG,FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 265卷 / 1-2期

关键词：

IMIDAZOLINE; CLONIDINE; BRAIN; HUMAN;

D O I：

10.1016/0014-2999(94)90234-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The first isolation of a human brain specific imidazoline binding protein is described. This protein was obtained using affinity chromatography and was revealed with the aid of an anti-idiotypic antibody specific for imidazoline binding sites. The protein (43 kDa) differs from other imidazoline binding proteins previously isolated from peripheral tissues, in particular by being also sensitive to clonidine.

引用

页码：R1 / R2

页数：2

共 8 条

[1] THE NUCLEUS RETICULARIS LATERALIS - A REGION HIGHLY SENSITIVE TO CLONIDINE [J].