FACTORS REGULATING THE FUNCTIONING OF THE INVITRO PERFUSED AGLOMERULAR KIDNEY OF THE ANGLERFISH, LOPHIUS-PISCATORIUS L

1. 1. Kidneys of Lophius were perfused from the renal portal vein with a Ringer's solution. 2. 2. Mammalian and piscine neurohypophysial hormones (in doses of 20-500 ng/kg body wt) did not affect the rate of urine production or the urinary concentration of inorganic ions. 3. 3. The rate of urine production and the urinary concentration of magnesium and sodium ions varied with the concentration of magnesium in the perfusate. 4. 4. The rate of urine production was positively correlated with urine magnesium concentration (r = 0.83 ± 0.04) and negatively correlated with that of sodium (r = -0.40). 5. 5. The urinary concentration of sodium ions varied inversely with that of magnesium ions (r = -0.89). 6. 6. Ouabain treatment (0.1-0.8 mM/l) reduced the rate of urine production by over 60% and altered, to varying extents, the pattern of electrolyte excretion. A simple model for the mode of formation of urine by the aglomerular kidney, based on the present results and other observations is suggested. © 1979.