NUCLEAR AND MITOCHONDRIAL EFFECTS OF ADRIAMYCIN IN SINGLY ISOLATED PULSATING MYOCARDIAL-CELLS

被引：22

作者：

LAMPIDIS, TJ ^{[1
]}

MORENO, G ^{[1
]}

SALET, C ^{[1
]}

VINZENS, F ^{[1
]}

机构：

[1] HOP BICETRE, INSERM, UNITE 48, INST PATHOL CELLULAIRE, F-94270 KREMLIN BICETRE, FRANCE

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 1979年 / 11卷 / 04期

关键词：

Adriamycin; Isolated heart cells;

D O I：

10.1016/0022-2828(79)90427-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Singly isolated mammalian myocardial cells beating in culture were utilized to investigate the possible mechanism of adriamycin cardiotoxicity. Two distinct effects were apparent 24 hours after treatment with 1.7 μg/ml of adriamycin: (1) nucleolar fragmentation, segregation, and chromatin clumping, as evidenced by phase contrast and electron microscopy; (2) inhibition of mitochondrial stimulatio, as revealed by u.v.-microbeam irradiation. The two effects, nuclear and mitochondrial, at early times seemed to be independent of each other. The ultrastructure of the mitochondria in treated cells appeared normal. © 1979.

引用

页码：415 / +

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