SELECTIVE SUPPRESSION OF THE TRANSCRIPTION OF RIBOSOMAL GENES IN MOUSE-HUMAN HYBRID-CELLS

被引：83

作者：

PERRY, RP ^{[1
]}

KELLEY, DE ^{[1
]}

SCHIBLER, U ^{[1
]}

HUEBNER, K ^{[1
]}

CROCE, CM ^{[1
]}

机构：

[1] UNIV PENN,WISTAR INST ANAT & BIOL,PHILADELPHIA,PA 19104

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 1979年 / 98卷 / 03期

关键词：

D O I：

10.1002/jcp.1040980313

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mouse‐human hybrid cells that preferentially segregate either mouse or human chromosomes were analyzed for their relative content of mouse and human rRNA genes and for their capacity to transcribe these genes. A distinctive Hind III restriction fragment containing 28S rRNA sequences was used to distinguish between mouse and human rDNA and a set of distinctive loop structures in the 45S pre‐rRNA was used to distinguish between mouse and human gene transcripts. Our results indicate that the genes of only one species are transcriptionally active in these hybrid cells, even though both sets of genes are present. Copyright © 1979 Wiley‐Liss, Inc.

引用

页码：553 / 559

页数：7

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