P-CHLOROPHENYLALANINE ATTENUATES THE PITUITARY-ADRENOCORTICAL RESPONSE TO 5-HT1A RECEPTOR AGONISTS IN MICE

被引：22

作者：

MATSUDA, T ^{[1
]}

KANDA, T ^{[1
]}

SEONG, YH ^{[1
]}

BABA, A ^{[1
]}

IWATA, H ^{[1
]}

机构：

[1] OSAKA UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,1-6 YAMADAOKA,SUITA,OSAKA 565,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 181卷 / 03期

关键词：

5-HT[!sub]1A[!/sub] receptors; 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin); ACTH; BP-554; Corticosterone; Hypothermia;

D O I：

10.1016/0014-2999(90)90092-K

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The i.p. injection of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) caused hypothermia and increased the concentrations of serum corticosterone and plasma ACTH in mice. The effects of 8-OH-DPAT at a dose of 2 mg/kg but not of 0.2 mg/kg on the hormone levels were attenuated by pretreatment with p-chlorophenylalanine (pCPA) which depleted brain 5-HT by about 70%; the hypothermic effect of 8-OH-DPAT was, however, not prevented. Similar results were obtained with another 5-HT1A agonist, 1-[3-(3,4-methylenedioxyphenoxy)propyl]-4-phenyl piperazine (BP-554). © 1990.

引用

页码：295 / 297

页数：3

共 9 条

[1] ACTIVATION OF THE 5-HT1A RECEPTOR SUBTYPE INCREASES RAT PLASMA ACTH CONCENTRATION [J].

GILBERT, F ;

BRAZELL, C ;

TRICKLEBANK, MD ;

STAHL, SM .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 147 (03) :431-439

[2] THE PHARMACOLOGY OF THE HYPOTHERMIC RESPONSE IN MICE TO 8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN (8-OH-DPAT) - A MODEL OF PRESYNAPTIC 5-HT1 FUNCTION [J].

GOODWIN, GM ;

DESOUZA, RJ ;

GREEN, AR .

NEUROPHARMACOLOGY, 1985, 24 (12) :1187-1194

[3] IDENTIFICATION OF PRE-SYNAPTIC SEROTONIN AUTORECEPTORS USING A NEW LIGAND - H-3-PAT [J].

GOZLAN, H ;

ELMESTIKAWY, S ;

PICHAT, L ;

GLOWINSKI, J ;

HAMON, M .

NATURE, 1983, 305 (5930) :140-142

[4] 8-OH-DPAT INCREASES CORTICOSTERONE BUT NOT OTHER 5-HT1A RECEPTOR-DEPENDENT RESPONSES MORE IN FEMALES [J].

HALEEM, DJ ;

KENNETT, GA ;

WHITTON, PS ;

CURZON, G .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 164 (03) :435-443

[5] HYPOTHERMIA IN THE RAT INDUCED BY THE POTENT SEROTONINERGIC AGENT 8-OH-DPAT [J].

HJORTH, S .

JOURNAL OF NEURAL TRANSMISSION, 1985, 61 (1-2) :131-135

[6] HYPOTHERMIA INDUCED BY THE PUTATIVE 5-HT1A AGONISTS LY165163 AND 8-OH-DPAT IS NOT PREVENTED BY 5-HT DEPLETION [J].

HUTSON, PH ;

DONOHOE, TP ;

CURZON, G .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 143 (02) :221-228

[7] SYNAPTIC INTERACTION OF SEROTONERGIC AXONS AND CORTICOTROPIN RELEASING-FACTOR (CRF) SYNTHESIZING NEURONS IN THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS OF THE RAT - A LIGHT AND ELECTRON-MICROSCOPIC IMMUNOCYTOCHEMICAL STUDY [J].

LIPOSITS, Z ;

PHELIX, C ;

PAULL, WK .

HISTOCHEMISTRY, 1987, 86 (06) :541-549

[8] AGONIST ACTIVITY OF A NOVEL COMPOUND, 1-[3-(3,4-METHYLENEDIOXYPHENOXY)PROPYL]-4-PHENYL PIPERAZINE (BP-554), AT CENTRAL 5-HT1A RECEPTORS [J].

MATSUDA, T ;

SEONG, YH ;

AONO, H ;

KANDA, T ;

BABA, A ;

SAITO, K ;

TOBE, A ;

IWATA, H .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 170 (1-2) :75-82

[9] 8-HYDROXY-2-(DI-NORMAL-PROPYLAMINO)-TETRALIN DISCRIMINATES BETWEEN SUBTYPES OF THE 5-HT1 RECOGNITION SITE [J].

MIDDLEMISS, DN ;

FOZARD, JR .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1983, 90 (01) :151-153

← 1 →