VACCINATION FOR DISEASE

被引：102

作者：

OEHEN, S ^{[1
]}

HENGARTNER, H ^{[1
]}

ZINKERNAGEL, RM ^{[1
]}

机构：

[1] UNIV ZURICH, INST PATHOL, EXPTL PATHOL LAB, CH-8091 ZURICH, SWITZERLAND

来源：

SCIENCE | 1991年 / 251卷 / 4990期

关键词：

D O I：

10.1126/science.1824801

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recombinant virus vaccines that express a limited number of epitopes are currently being developed to prevent disease by changing the relative balance between viral spread and the immune response. Some circumstances, however, were found in infections with a noncytopathic virus in which vaccination caused disease; sensitive parameters included the genetic background of the host, the time or dose of infection, and the constituents of the vaccine. Thus, immunopathologic damage by T cells may be an unwanted consequence of vaccination with the new types of peptide or recombinant vaccines that are being investigated for the human immunodeficiency viruses and other pathogens.

引用

页码：195 / 198

页数：4

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