PRODUCTION OF GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR BY CULTURED ASTROCYTES

被引：65

作者：

OHNO, K

SUZUMURA, A

SAWADA, M

MARUNOUCHI, T

机构：

[1] NAGOYA CITY UNIV,FAC PHARMACEUT SCI,DEPT BIOL CHEM,NAGOYA,AICHI 467,JAPAN

[2] FUJITA HLTH UNIV,SCH MED,DEPT NEUROL,TOYOAKE,AICHI,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 169卷 / 02期

关键词：

D O I：

10.1016/0006-291X(90)90390-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the production of interleukin-3 (IL-3)-like factor by murine astrocytes. Supernatants from lipopolysaccharide (LPS)-stimulated astrocytes induced proliferation of IC-2, an IL-3- and granulocyte/macrophage colony-stimulating factor (GM-CSF)-dependent cell line. This activity was completely neutralized by the antibody against GM-CSF but not by the anti-IL-3 monoclonal antibody. Northern blot analysis revealed the expression of GM-CSF mRNA, but not of IL-3 mRNA, in cultured astrocytes. These results indicate that with proper stimuli murine astrocytes produce GM-CSF. © 1990.

引用

页码：719 / 724

页数：6

共 15 条

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