BIOCHEMICAL AND PHARMACOLOGICAL PROPERTIES OF A CARDIOTOXIC FACTOR ISOLATED FROM THE BLOOD-SERUM OF BURNED PATIENTS

被引：11

作者：

MOATI, F ^{[1
]}

SEPULCHRE, C ^{[1
]}

MISKULIN, M ^{[1
]}

HUISMAN, O ^{[1
]}

MOCZAR, E ^{[1
]}

ROBERT, AM ^{[1
]}

MONTEIL, R ^{[1
]}

GUILBAUD, J ^{[1
]}

机构：

[1] HOP INSTRUCT ARMEES PERCY, CTR NATL INTERARMEES TRAITEMENT GRANDS BRULES, F-92141 CLAMART, FRANCE

来源：

JOURNAL OF PATHOLOGY | 1979年 / 127卷 / 03期

关键词：

D O I：

10.1002/path.1711270307

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Blood serum of severely burned patients contains several substances which are not present in normal sera. One of these substances, a small protein of an approximate MW of 12-14,000 daltons, displayed a toxic action on the circulatory system. This cardiotoxic factor was obtained in a purified form by alcohol precipitation followed by gel filtration and carboxymethyl cellulose chromatography. The purified preparation seemed to be a low MW protein of about 8000 daltons. The biological effects of this substance consisted essentially of ECG alterations indicating decreased cardiac output and of cardiac muscle ischemia. The blood pressure decreased and respiratory function was altered. The presence of such a toxic factor in sufficient concentration in the blood serum may explain the cardiovascular complications in some burned patients.

引用

页码：147 / 156

页数：10

共 11 条

[1]

HAKIM AA, 1973, P SOC EXP BIOL MED, V144, P359

[2]

KENEDI I, 1966, ACTA PHYSIOL HUNG, V29, P63

[3] RELATIONSHIP OF PLASMA PEPTIDES TO MYOCARDIAL DEPRESSANT FACTOR IN HEMORRHAGIC SHOCK IN CATS [J].