ADDUCT FORMATION AT C-8 OF GUANINE ON INVITRO REACTION OF THE ULTIMATE FORM OF 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE WITH 2'-DEOXYGUANOSINE AND ITS PHOSPHATE-ESTERS

被引：60

作者：

NAGAOKA, H ^{[1
]}

WAKABAYASHI, K ^{[1
]}

KIM, SB ^{[1
]}

KIM, IS ^{[1
]}

TANAKA, Y ^{[1
]}

OCHIAI, M ^{[1
]}

TADA, A ^{[1
]}

NUKAYA, H ^{[1
]}

SUGIMURA, T ^{[1
]}

NAGAO, M ^{[1
]}

机构：

[1] UNIV SHIZUOKA, SCH PHARMACEUT SCI, OYA, SHIZUOKA 422, JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1992年 / 83卷 / 10期

关键词：

PHIP; N-OH-PHIP; DEOXYGUANOSINE; DG-C8-PHIP;

D O I：

10.1111/j.1349-7006.1992.tb02716.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examined the reactivity of the N-hydroxyamino derivative of a carcinogenic heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), after its O-acetylation with four 2'-deoxyribonucleoside 3'-monophosphates. P-32-Postlabeling analysis demonstrated that the levels of adducts with 2'-deoxyguanosine 3'-monophosphate were much higher than those with the other three nucleotides. H-1-NMR, mass spectral and UV absorption spectral analyses of the major adducts formed by N-acetoxy-PhIP with 2'-deoxyguanosine and with its phosphate esters indicated that PhIP bound at the C-8 position of guanine, as previously demonstrated with other heterocyclic amines.

引用

页码：1025 / 1029

页数：5

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