ENDOTHELIN-1 ENHANCES VASCULAR-PERMEABILITY IN THE RAT-HEART THROUGH THE ETA RECEPTOR

被引：49

作者：

FILEP, JG

FOLDESFILEP, E

ROUSSEAU, A

FOURNIER, A

SIROIS, P

YANO, M

机构：

[1] INST NATL RECH SCI SANTE,MONTREAL,QUEBEC,CANADA

[2] BANYU PHARMACEUT CO,CENTR RES LABS,TSUKUBA,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 219卷 / 02期

关键词：

ENDOTHELIN-1; VASCULAR PERMEABILITY; CORONARY CIRCULATION;

D O I：

10.1016/0014-2999(92)90318-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Intravenous injection of endothelin-I (ET-1, 0.1 and 1 nmol/kg) resulted in a dose-dependent increase in vascular permeability in the coronary circulation of conscious rats. The increase was almost completely abolished by the selective ET(A) receptor antagonist, BQ-123 (1 mg/kg). The ET-1 analogue, [Trp(For)21]ET-1, which is devoid of the depressor but not the pressor activity, evoked changes in protein extravasation similar to those with ET-1. These data indicate that the permeability effect of ET-1 is mediated through the ET(A) receptor.

引用

页码：343 / 344

页数：2

共 6 条

[1] INFLAMMATION IN THE COURSE OF EARLY MYOCARDIAL-ISCHEMIA [J].