ISOLATION AND STRUCTURE OF THE REMARKABLE HUMAN CANCER CELL-GROWTH INHIBITORS SPONGISTATIN-2 AND SPONGISTATIN-3 FROM AN EASTERN INDIAN OCEAN-SPONGIA SP

被引：119

作者：

PETTIT, GR

CICHACZ, ZA

GAO, F

HERALD, CL

BOYD, MR

机构：

[1] ARIZONA STATE UNIV,DEPT CHEM,TEMPE,AZ 85287

[2] NCI,FREDERICK CANC RES & DEV CTR,DIV CANC TREATMENT,DRUG DISCOVERY RES & DEV LAB,FREDERICK,MD 21702

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1993年 / 14期

关键词：

D O I：

10.1039/c39930001166

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A black Spongia SP. in the Porifera class Demospongiae had been found to contain two new and exceptionally potent cell (human cancer) growth inhibitors named spongistatins 2 (1b) and 3 (1c).

引用

页码：1166 / 1168

页数：3

共 18 条

[1] BAI R, 1991, J BIOL CHEM, V266, P15882
[2] Boyd M. R., 1993, CURRENT THERAPY ONCO, P11
[3] BOYD MR, 1989, PRINCIPLES PRACTICES, V10, P1
[4] BOYD MR, 1992, CYTOTOXIC ANTICANCER, P11
[5] BIOACTIVE MARINE METABOLITES .35. CYTOTOXIC METABOLITES OF THE MARINE SPONGE MYCALE-ADHAERENS LAMBE
FUSETANI, N
SUGAWARA, T
MATSUNAGA, S
HIROTA, H
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (16) : 4971 - 4974
[6] GABRIELSEN B, 1992, NATURAL PRODUCTS AS ANTIVIRAL AGENTS, P121
[7] GRANT S, 1992, LEUKEMIA, V6, P432
[8] HORNUNG RL, 1992, CANCER RES, V52, P101
[9] 8 NEW CYTOTOXIC METABOLITES CLOSELY RELATED TO ONNAMIDE-A FROM 2 MARINE SPONGES OF THE GENUS THEONELLA
MATSUNAGA, S
FUSETANI, N
NAKAO, Y
[J]. TETRAHEDRON, 1992, 48 (39) : 8369 - 8376
[10] EFFECT OF PHARMACOLOGICAL MANIPULATION OF PROTEIN-KINASE-C BY PHORBOL DIBUTYRATE AND BRYOSTATIN-1 ON THE CLONOGENIC RESPONSE OF HUMAN GRANULOCYTE-MACROPHAGE PROGENITORS TO RECOMBINANT GM-CSF
MCCRADY, CW
STANISWALIS, J
PETTIT, GR
HOWE, C
GRANT, S
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 1991, 77 (01) : 5 - 15

← 1 2 →