HEPT DERIVATIVES - 6-BENZYL-1-ETHOXYMETHYL-5-ISOPROPYLURACIL (MKC-442)

被引：39

作者：

BABA, M

TANAKA, H

MIYASAKA, T

YUASA, S

UBASAWA, M

WALKER, RT

DECLERCQ, E

机构：

[1] SHOWA UNIV,DEPT SYNTHET CHEM,TOKYO 142,JAPAN

[2] MITSUBISHI KASEI CORP,RES CTR,YOKOHAMA,KANAGAWA 227,JAPAN

[3] UNIV BIRMINGHAM,DEPT CHEM,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

[4] CATHOLIC UNIV LEUVEN,REGA INST MED RES,B-3000 LOUVAIN,BELGIUM

来源：

NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 3-5期

关键词：

D O I：

10.1080/15257779508012431

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) derivatives have been found to be potent and specific inhibitors of human immunodeficiency virus type 1 (HIV-1) replication in vitro. Among the compounds, MKC-442 (6-benzyl-1-ethoxymethyl-5-isopropyluracil) has recently been chosen as a candidate for clinical efficacy and safety studies in patients with the acquired immune deficiency syndrome (AIDS).

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页码：575 / 583

页数：9

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