THE CARBOXYLIC-ACID GROUP AS AN EFFECTIVE DIRECTOR OF ORTHO-LITHIATION

被引：79

作者：

MORTIER, J

MOYROUD, J

BENNETAU, B

CAIN, PA

机构：

[1] UNIV BORDEAUX 1,CHIM ORGAN & ORGANOMET LAB,CNRS,URA 35,F-33405 TALENCE,FRANCE

[2] RHONE POULENC AG CO,RES TRIANGLE PK,NC 27709

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1994年 / 59卷 / 15期

关键词：

D O I：

10.1021/jo00094a007

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of PhCO(2)H in tetrahydrofuran with 2.2 equiv of a 1:1 sec-butyllithium/N,N,N',N'-tetramethyl-1,2-ethylenediamine complex at -90 degrees C gave o-LiC6H4CO2Li, which was treated with electrophiles to give o-RC(6)H(4)CO(2)H (R = Me, SMe, Cl, Br) in good yields.

引用

页码：4042 / 4044

页数：3

共 47 条

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