ONLINE LIQUID-CHROMATOGRAPHY NUCLEAR-MAGNETIC-RESONANCE MASS-SPECTROMETRY - A POWERFUL SPECTROSCOPIC TOOL FOR THE ANALYSIS OF MIXTURES OF PHARMACEUTICAL INTEREST

被引：65

作者：

PULLEN, FS

SWANSON, AG

NEWMAN, MJ

RICHARDS, DS

机构：

[1] Department of Physical Sciences, Pfizer Central Research, Sandwich, Kent, CT139NJ, Ramsgate Road

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 1995年 / 9卷 / 11期

关键词：

D O I：

10.1002/rcm.1290091106

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Liquid chromatography (LC), simultaneously coupled with both nuclear magnetic resonance (NMR) and mass spectrometry (MS) 'on-line' is a powerful structural tool and has a potentially vast range of uses within the pharmaceutical industry. Data from a mixture of fluconazole and related triazoles have been obtained from an LC/NMR-MS system developed 'in-house', demonstrating the power of this novel analytical approach.

引用

页码：1003 / 1006

页数：4