SALTING EFFECTS IN REVERSED MOBILE PHASES ON CHIRAL SEPARATION OF BENZONAPHTHAZEPINE STEREOISOMERS

被引：12

作者：

NING, JG

机构：

[1] Schering-Plough Research Institute, Department of Chemical Development Control and Compliance, Union, NJ 07083

来源：

JOURNAL OF CHROMATOGRAPHY A | 1994年 / 659卷 / 02期

关键词：

D O I：

10.1016/0021-9673(94)85071-2

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The salting-in effect of NaClO4 in reversed mobile phases versus the salting-out effect of NaCl on the separation of benzonaphthazepine (BNA) stereoisomers was evaluated. The critical role of NaClO4 in the mobile phase was examined. A hypothesis was proposed on the salting-in effect compared with the effect of ion-pair reagents. A mechanism of separation of BNA stereoisomers was suggested based on molecular modeling of BNA enantiomers and diastereomers.

引用

页码：299 / 305

页数：7

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