IS ENDOTHELIN-1 RELEASE AT REPERFUSION OF THE ISCHEMIC HUMAN HEART DUE TO COLD-INDUCED DISPLACEMENT OF ENDOTHELIN FROM BINDING-SITES

被引：9

作者：

FRANCOCERECEDA, A

BARR, G

OWALL, A

LISKA, J

LUNDBERG, JM

机构：

[1] KAROLINSKA HOSP,DEPT CARDIOTHORAC ANAESTHET & INTENS CARE,S-17176 STOCKHOLM,SWEDEN

[2] KAROLINSKA INST,DEPT PHYSIOL & PHARMACOL,STOCKHOLM,SWEDEN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 279卷 / 01期

关键词：

ENDOTHELIN; HEART; ISCHEMIA; RECEPTOR DISPLACEMENT;

D O I：

10.1016/0014-2999(95)00213-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Following reperfusion of ischaemic human hearts subjected to cold (4 degrees C) cardioplegia during coronary bypass surgery, there was an increase in cardiac outflow of endothelin-1 but not the pro-peptide big endothelin-l. Furthermore, specific endothelin-l binding in human lung membrane preparations was displaced by incubation in buffer medium at 4 degrees C. The present results thus indicate that cold-induced displacement of endothelin-l binding, rather than increased synthesis, may explain the cardiac release of endothelium-l following ischaemia during heart surgery in which cold cardioplegia has been used.

引用

页码：105 / 107

页数：3

共 11 条

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