SPONTANEOUS ACTIVITY AND RESPONSES OF RETICULAR NEURONS IN MONOAMINE-DEPLETED RATS

被引：1

作者：

BRIGGS, I ^{[1
]}

TEMPESTA, E ^{[1
]}

机构：

[1] MED SCH BIRMINGHAM,MRC,NEUROPHARMACOL UNIT,BIRMINGHAM B15 2TJ,W MIDLANDS,ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 57卷 / 2-3期

关键词：

Monoamine depletion; p-Chlorophenylalanine; Reserpine; Reticular neurones; Serotonin; Supersensitivity;

D O I：

10.1016/0014-2999(79)90361-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Depletion of rat brain serotonin by p-chlorophenylalanine (PCPA) pretreatment, or of monoamines by reserpine pretreatment, was associated with reduced spontaneous firing rates of bulbar reticular neurones. Administration of 5-hydroxytryptophan to PCPA-treated rats reversed the reduction of neuronal activity. It is suggested that the results indicate a tonic excitatory serotoninergic input to a significant proportion of these neurones, which is abolished by serotonin depletion. Responses to serotonin and noradrenaline were greater in PCPA-treated and reserpine-treated rats respectively, indicating the development of supersensitivity. © 1979.

引用

页码：165 / 169

页数：5

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