A METHOD (COMPETITIVE PROTEIN-BINDING) FOR DETERMINATION OF PLASMA-TESTOSTERONE LEVEL - STUDY OF TESTOSTERONE METABOLISM IN MEN OVER 60 YEARS

A Method (Competitive Protein-binding) for Determination of Plasma-Testosterone Level; Study of Testosterone Metabolism in Men Over 60 Years The author describes a method fordetermination of male scx-hormonc in plasma which belongs in the group of 'protein-binding' procedures and is sensitive and exact. The limit of sensitivity is 0.1 ng (1 ng = 10-9 g)Using the method described, testosterone levels were determined in 21 normal young men (mean value: 0.74 ± 0.29 SD µg/100 ml plasma) and in G8 men over GO years (mean value: 0.43 ± 0.25 SD). In addition, plasma-testostcrone values were determined in 17 men over GO, both before and after administration of 5,000 units of gonadotropin. In addition, in 17 men over GO testicular morphology was correlated with plasma- testostcrone values. © 1969 S. Karger AG, Basel.