MEASUREMENT OF LYSERGIC-ACID DIETHYLAMIDE (LSD) IN HUMAN PLASMA BY GAS-CHROMATOGRAPHY NEGATIVE-ION CHEMICAL IONIZATION MASS-SPECTROMETRY

被引：32

作者：

PAPAC, DI ^{[1
]}

FOLTZ, RL ^{[1
]}

机构：

[1] UNIV UTAH,CTR HUMAN TOXICOL,SALT LAKE CITY,UT 84108

来源：

JOURNAL OF ANALYTICAL TOXICOLOGY | 1990年 / 14卷 / 03期

关键词：

D O I：

10.1093/jat/14.3.189

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A previously reported procedure for quantification of LSD in urine was modified to permit measurement of the drug in plasma. After addition of deuterium-labeled LSD, the plasma is extracted and the extract is treated with trifluoroacetylimidazole to convert the LSD to its N-trifluoroacetyl derivative. The derivatized LSD is analyzed by capillary column gas chromatography/negative ion chemical ionization. Plasma fortified with known concentrations of LSD gave linear responses from 0.1 to 3.0 ng/mL with this assay. The method was used to determine pharmacokinetic parameters for LSD after oral administration (1 μg/kg) to a male volunteer. The apparent plasma half-life was determined to be 5.1 h. The peak plasma concentration of 1.9 ng/mL occurred 3 h after administration. © 1990 Oxford University Press.

引用

页码：189 / 190

页数：2