THE EFFECT OF FOSINOPRIL SODIUM ON CEREBRAL BLOOD-FLOW IN MODERATE ESSENTIAL-HYPERTENSION

被引:26
作者
WALDEMAR, G
IBSEN, H
STRANDGAARD, S
ANDERSEN, AR
RASMUSSEN, S
PAULSON, OB
机构
[1] The Departments of Neurology Rigshospitalet, Copenhagen
[2] Cardiology, Rigshospitalet, Copenhagen
[3] Department of Internal Medicine, Holbøk County Hospital
[4] Department of Internal Medicine C, Glostrup Hospital, Copenhagen
关键词
Angiotensin converting enzyme; Cerebral blood flow; Fosinopril;
D O I
10.1093/ajh/3.6.464
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
The effect of the angiotensin converting enzyme (ACE) inhibitor fosinopril sodium on regional cerebral blood flow (rCBF) was investigated in 8 patients with moderate essential hypertension. A constant dose of chlorthalidone (25 mg/day) was given to stimulate the renin angiotensin system, and fosinopril sodium was given in incremental doses (10 to 40 mg/day) with the aim of obtaining a diastolic blood pressure at or below 90 mm Hg. Regional CBF was measured with xenon-133 inhalation tomography. Repetitive measurements were made at the start of treatment and again after 4 to 12 weeks treatment in the resting supine position, and during lower body negative pressure (LBNP) as a substitute for the upright position. Four hours after the first 10 mg dose of fosinopril the mean arterial pressure (MAP) had been reduced from 127 ± 13 mm Hg to 105 ± 9 mm Hg (P <. 01) without any significant change in mean CBF (55 ± 9 mL/(100 g × min) at baseline versus 52 ± 9 mL/(100 g × min) after fosinopril). After prolonged treatment with chlorthalidone and fosinopril, mean CBF was still unchanged from baseline levels, when measured 4 and 24 h after a single dose of fosinopril, despite a 10% reduction in MAP (P <. 01). LBNP did not lead to any significant change in rCBF. The regional distribution of CBF was normal in all patients throughout the study. We conclude that treatment with fosinopril sodium causes a moderate fall in blood pressure without any adverse effects on rCBF. © 1990 by the American Journal of Hypertension, Ltd.
引用
收藏
页码:464 / 470
页数:7
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