KARYOTYPIC CHARACTERIZATION OF ESTABLISHED CELL-LINES DERIVED FROM A SQUAMOUS-CELL CARCINOMA AND AN ADENOCARCINOMA OF HUMAN LUNG CANCERS

被引：16

作者：

ERDEL, M

PETER, W

SPIESS, E

TREFZ, G

EBERT, W

机构：

[1] GERMAN CANC RES CTR,INST CELL & TUMOR BIOL,IM NEUENHEIMER FELD 280,W-6900 HEIDELBERG,GERMANY

[2] THORAXKLIN HEIDELBERG ROHRBACH,DEPT CLIN CHEM,HEIDELBERG,GERMANY

来源：

CANCER GENETICS AND CYTOGENETICS | 1990年 / 49卷 / 02期

关键词：

D O I：

10.1016/0165-4608(90)90141-V

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Two non-small cell carcinoma cell lines from the major histopathologic groups of human lung cancers have been karyotyped: HS-24 was established from a squamous cell carcinoma, and SB-3 was obtained from a metastasis of a poorly differentiated adenocarcinoma. Endoreduplication is characteristic for both cell lines. Subsequent loss of chromosomes led finally to hypotetraploid karyotypes with modal chromosome numbers of 66-68 and 70-72 for HS-24 and SB-3, respectively. The structural analysis was performed by G- and C-banding. Stable overrepresentation of chromosomes 7, 8, 12, and 16 was found. Both cell lines developed a characteristic set of disomic and stable markers. Chromosomes involved in markers were 1, 2, 5, 6, 10, 11, 16, and 17. Consistent numerical and structural normality for chromosomes 4, 18, and 21 was observed. © 1990.

引用

页码：185 / 198

页数：14

共 40 条

[1] BURHOLT D R, 1989, Proceedings of the American Association for Cancer Research Annual Meeting, V30, P37
[2] BURHOLT DR, 1989, CANCER RES, V49, P3355
[3] CYTOGENETIC ABNORMALITIES COMMON TO ADENOCARCINOMA METASTATIC TO THE PLEURA
CAGLE, PT
TAYLOR, LD
SCHWARTZ, MR
RAMZY, I
ELDER, FFB
[J]. CANCER GENETICS AND CYTOGENETICS, 1989, 39 (02) : 219 - 225
[4] CYTOGENETIC STUDIES OF 4 HUMAN-LUNG ADENOCARCINOMA CELL-LINES
FAN, YS
LI, P
[J]. CANCER GENETICS AND CYTOGENETICS, 1987, 26 (02) : 317 - 325
[5] FIDLER IJ, 1981, J NATL CANCER I, V67, P947
[6] NUMERICAL CHROMOSOME-ABERRATIONS IN HUMAN NEOPLASIA
HEIM, S
MITELMAN, F
[J]. CANCER GENETICS AND CYTOGENETICS, 1986, 22 (02) : 99 - 108
[7] ISOCHROMOSOMES I(8Q) OR I(9Q) IN 3 ADENOCARCINOMAS OF THE LUNG
JIN, YS
MANDAHL, N
HEIM, S
SCHULLER, H
MITELMAN, F
[J]. CANCER GENETICS AND CYTOGENETICS, 1988, 33 (01) : 11 - 17
[8] RESTRICTION FRAGMENT LENGTH POLYMORPHISM STUDIES SHOW CONSISTENT LOSS OF CHROMOSOME-3P ALLELES IN SMALL CELL LUNG-CANCER PATIENTS TUMORS
JOHNSON, BE
SAKAGUCHI, AY
GAZDAR, AF
MINNA, JD
BURCH, D
MARSHALL, A
NAYLOR, SL
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1988, 82 (02) : 502 - 507
[9] DNA POLYMORPHISMS INDICATE LOSS OF HETEROZYGOSITY FOR CHROMOSOME-11 OF D98AH2 CELLS
KAELBLING, M
ROGINSKI, RS
KLINGER, HP
[J]. CYTOGENETICS AND CELL GENETICS, 1986, 41 (04): : 240 - 244
[10] SUPPRESSION OF TUMORIGENICITY IN SOMATIC-CELL HYBRIDS .3. COSEGREGATION OF HUMAN CHROMOSOME-11 OF A NORMAL-CELL AND SUPPRESSION OF TUMORIGENICITY IN INTRASPECIES HYBRIDS OF NORMAL DIPLOID X MALIGNANT-CELLS
KAELBLING, M
KLINGER, HP
[J]. CYTOGENETICS AND CELL GENETICS, 1986, 41 (02): : 65 - 70

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