FATTY-ACID PATTERN OF THE DIFFERENT PHOSPHOINOSITIDE FRACTIONS IN HUMAN MENINGIOMAS

被引：2

作者：

BERRA, B ^{[1
]}

BORDONI, A ^{[1
]}

BIAGI, PL ^{[1
]}

RAPELLI, S ^{[1
]}

HRELIA, S ^{[1
]}

机构：

[1] UNIV BOLOGNA,DEPT BIOCHEM,I-40126 BOLOGNA,ITALY

来源：

MOLECULAR AND CHEMICAL NEUROPATHOLOGY | 1991年 / 15卷 / 03期

关键词：

HUMAN MENINGIOMAS; PHOSPHOINOSITIDES; IN HUMAN MENINGIOMAS; FATTY ACID COMPOSITION; POLYUNSATURATED FATTY ACIDS; ANALYSIS OF THE DIFFERENT FRACTIONS;

D O I：

10.1007/BF03161063

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous studies showed no differences in the phospholipid content of human meningiomas compared to normal leptomeninges, but only a higher unsaturation degree in the individual phospholipid fractions of tumors. Inasmuch as phosphoinositides play a role in the membrane responsiveness to numerous effectors, we studied the fatty acid pattern of the different phosphoinositide fractions of 14 human meningiomas of different histological origin. The fatty acid analysis revealed remarkable differences among the histological types, and, above all, among the different phosphoinositide fractions of a single tumor class. The phosphoinositides derived from transitional meningiomas appeared to be the most saturated ones, because of their low arachidonic acid content. Furthermore, in all the meningiomas, long chain polyunsaturated fatty acids were present only in the phosphatidylinositol fractions and the polyphosphorylated compounds appeared to be significantly different from the corresponding monophosphorylated ones. The possible significance of the different fatty acid distribution in the three phosphoinositide classes is discussed.

引用

页码：249 / 259

页数：11

共 26 条

[1] POSITIONAL DISTRIBUTION AND TURNOVER OF FATTY-ACIDS IN PHOSPHATIDIC ACID, PHOSPHOINOSITIDES, PHOSPHATIDYLCHOLINE AND PHOSPHATIDYLETHANOLAMINE IN RAT-BRAIN IN-VIVO [J].