DIFFERENTIAL-EFFECTS OF PEPTIDE-HORMONES BOMBESIN, VASOACTIVE INTESTINAL POLYPEPTIDE AND SOMATOSTATIN ANALOG RC-160 ON THE INVASIVE CAPACITY OF HUMAN PROSTATIC-CARCINOMA CELLS

被引：135

作者：

HOOSEIN, NM ^{[1
]}

LOGOTHETIS, CJ ^{[1
]}

CHUNG, LWK ^{[1
]}

机构：

[1] UNIV TEXAS,M D ANDERSON CANC CTR,DEPT MED ONCOL,HOUSTON,TX 77030

来源：

JOURNAL OF UROLOGY | 1993年 / 149卷 / 05期

关键词：

PROSTATIC NEOPLASMS; NEOPLASM METASTASIS; BOMBESIN; VASOACTIVE INTESTINAL PEPTIDE; ADENOSINE CYCLIC MONOPHOSPHATE;

D O I：

10.1016/S0022-5347(17)36349-8

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of bombesin, vasoactive intestinal polypeptide (VIP), and a somatostatin analog (RC-160) on the in vitro invasion of reconstituted basement membrane (Matrigel) by two human prostatic carcinoma cell lines were examined. Aggressively growing PC-3 cells were found to be invasive in this assay in contrast to the relatively indolent LNCaP cells. Bombesin increased penetration of basement membrane by both cell lines. Although VIP had no effect on invasion by PC-3 cells, it enhanced invasion by LNCaP cells in a dose-dependent manner. In agreement with these results, VIP stimulated adenylate cyclase activity only in LNCaP cells. In contrast to bombesin and VIP, RC-160 did not alter invasion by either cell line. Our results suggest that certain neuroendocrine peptides can increase the invasive potential of prostatic carcinoma cells and may thereby contribute to the rapid progression and aggressive clinical course of prostate tumors containing neuroendocrine elements.

引用

页码：1209 / 1213

页数：5

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