AN HPLC STUDY OF TINIDAZOLE HYDROLYSIS

被引:11
作者
SALOMIES, H
SALO, JP
机构
[1] Pharmaceutical Chemistry Division, Department of Pharmacy, University of Helsinki, Helsinki, 00170
关键词
COLUMN LIQUID CHROMATOGRAPHY; TINIDAZOLE; HYDROLYSIS; KINETICS;
D O I
10.1007/BF02263842
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The high-performance liquid chromatographic (HPLC) method herein described allows the simultaneous determination of the hydrolysis kinetics of tinidazole and the formation kinetics of the hydrolysis products. Tinidazole is easily hydrolysed under basic conditions at raised temperature. The rate varies with the pH and the temperature of the solution, and the decomposition follows apparent first-order kinetics. The Arrhenius equation can be used to describe the effect of temperature on the half-life.
引用
收藏
页码:79 / 82
页数:4
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