MYELIN BASIC-PROTEIN GENE POLYMORPHISM IS NOT ASSOCIATED WITH CHRONIC PROGRESSIVE MULTIPLE-SCLEROSIS

被引：19

作者：

VANDEVYVER, C

STINISSEN, P

CASSIMAN, JJ

RAUS, J

机构：

[1] LIMBURGS UNIV CENTRUM,DEPT PHYSIOL,DIEPENBEEK,BELGIUM

[2] KATHOLIEKE UNIV LEUVEN,CENTRUM MENSELIJKE ERFELIJKHEID,B-3001 LOUVAIN,BELGIUM

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1994年 / 52卷 / 01期

关键词：

MULTIPLE SCLEROSIS; SUSCEPTIBILITY; MYELIN BASIC PROTEIN;

D O I：

10.1016/0165-5728(94)90167-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the present study a tetranucleotide (TGGA)n repeat polymorphism 5' to the myelin basic protein (MBP) gene was evaluated in a group of HLA-class II-typed, chronic progressive multiple sclerosis (MS) patients. This polymorphism has been reported by others to be associated with MS. Contrary to these reports we observed similar allele frequencies in patients and controls. Our results indicate that there is no association between MS and a polymorphism 5' to the MBP gene.

引用

页码：97 / 99

页数：3

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