SYNTHESIS OF A DELTA-1,6-1-CARBACEPHEM-4-CARBOXYLIC ACID-DERIVATIVE AS PROTOTYPE FOR A NEW FAMILY OF FUSED BICYCLIC BETA-LACTAMS

被引：12

作者：

BACHI, MD

BARNER, N

机构：

[1] Department of Organic Chemistry, The Weizmann Institute Of Science, Rehovot

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(01)80973-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of 7-phenoxy-1-carbaceph-1,6-em-4-carboxylic acid 4 is described. The synthetic method involves the construction of a 8-oxo-1-azabicyclo[4.2.0]octane ring system through tri-n-butylstannane mediated free-radical annelation, and the introduction of the double bond at the bridgehead of a 8-oxo-1-azabicyclo[4.2.0]octene ring system by thermolysis of a sulfoxide group at position-6.

引用

页码：2439 / 2442

页数：4

共 20 条

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