CHLORINATED HYDROCARBON INSECTICIDE RESIDUES IN TISSUES OF RATS BEFORE AND AFTER REDUCTION OF BODY-FAT BY DIETARY RESTRICTION

Male weanling rats were fed ad libitum until 250 days of age one of three nutritionally adequate diets with or without the addition of 2.80 ppm of a chlorinated hydrocarbon insecticide (CHI) mixture. The mixture comprised DDT, TDE, DDE, lindane, dieldrin, and perthane. Between 251 and 300 days of age, half of the rats in eachgroup were restricted to 50% of their ad libitum food intake. Concentration and total amounts of each insecticide were determined in adipose tissue, liver, and brain. Deposition, and mobilization during weight reduction, of insecticides varied with diet and tissue examined. When food intake was reduced, total DDT amount did not change in the three tissues regardless of diet. However, total amounts of DDT metabolites and dieldrin were altered withreduced intake. Differences associated with diet occurred primarily in adipose and liver tissues. Total DDT amount was not affected by diet. © 1979, American Chemical Society. All rights reserved.