IMPAIRMENT OF DELAYED MATCHING IN MONKEYS BY CHLORPROMAZINE AND PENTOBARBITAL

被引：21

作者：

GLICK, SD

GOLDFARB, TL

ROBUSTELLI, F

GELLER, A

JARVIK, ME

机构：

[1] Department of Pharmacology, Albert Einstein College of Medicine, New York

来源：

PSYCHOPHARMACOLOGIA | 1969年 / 15卷 / 02期

关键词：

Chlorpromazine; Delayed Matching; Memory; Motor Impairment; Pentobarbital; Sedation;

D O I：

10.1007/BF00407045

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Monkeys trained to perform in a delayed matching test under five delay conditions were given chlorpromazine hydrochloride (0.05, 0.1, 0.2 and 0.4 mg/kg) and pentobarbital sodium (1.0, 10.0 and 20.0 mg/kg) before test sessions. Both drugs decreased response rate proportionally as dose increased. Chlorpromazine initially depressed accuracy, but showed no specific effects as delay interval increased. Pentobarbital had little effect upon accuracy, although impairment on the simultaneous conditions was seen at the highest dose. It is concluded that neither drug produced specific effects upon short-term memory. © 1969 Springer-Verlag.

引用

页码：125 / +

页数：1