CLOBAZAM - PHARMACOLOGICAL AND THERAPEUTIC PROFILE

1 Clobazam is a 1,5‐benzodiazepine the pharmacological profile of which differs from that of the 1,4 benzodiazepines in that it displays a wide separation of psychosedative or 'tranquillizing' properties from impairment of motor coordination. This is associated with a relative lack of muscle relaxant activity. 2 In man it seems to be an effective anxiolytic agent when given in daily doses of 20‐30 mg but produces minimal effects on psychomotor performance at these dose levels. 3 Clobazam has a long elimination half‐life of about 18 h; the main metabolite is N‐desmethylclobazam. Clobazam seems to share the good safety and tolerability characteristics of the 1,4 benzodiazepines. 1979 The British Pharmacological Society