INSULIN-LIKE GROWTH FACTOR-I (IGF-I) DISTRIBUTION IN THE TISSUE AND EXTRACELLULAR COMPARTMENT IN DIFFERENT REGIONS OF RAT-BRAIN

被引：44

作者：

YAMAGUCHI, F

ITANO, T

MIZOBUCHI, M

MIYAMOTO, O

JANJUA, NA

MATSUI, H

TOKUDA, M

OHMOTO, T

HOSOKAWA, K

HATASE, O

机构：

[1] KAGAWA MED SCH,DEPT NEUROSURG,KITA,KAGAWA 76107,JAPAN

[2] KAGAWA MED SCH,DEPT PHYSIOL,KITA,KAGAWA 76107,JAPAN

来源：

BRAIN RESEARCH | 1990年 / 533卷 / 02期

关键词：

Autocrine; Distribution; Insulin-like growth factor I; Intracerebral microdialysis; Paracrine; Rat brain;

D O I：

10.1016/0006-8993(90)91361-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The regional distribution of insulin-like growth favtor I (IGF-I) was examined in the tissue and extracellular compartment of rat brain. The tissue content of IGF-I was the highest in the pituitary gland, followed by the olfactory bulb, upper brainstem, cerebellum, striatum, hippocampus, lower brainstem, and cerebral cortex. The extracellular concentration was studied by intracerebral microdialysis technique, and the highest content was found in the hippocampus, followed by the olfactory bulb, hypothalamus, cerebellum, striatum, and cerebral cortex. The tissue and extracellular contents were significantly correlated in the olfactory bulb, hypothalamus, cerebellum, striatum, and cerebral cortex. IGF-I might act by paracrine and/or autocrine regulatory mechanisms in these regions. © 1990.

引用

页码：344 / 347

页数：4

共 29 条

[1] INSULIN-LIKE GROWTH FACTOR-I (SOMATOMEDIN-C) RECEPTORS IN THE RAT-BRAIN - DISTRIBUTION AND INTERACTION WITH THE HIPPOCAMPAL CHOLINERGIC SYSTEM [J].