STUDIES ON ORALLY ACTIVE CEPHALOSPORIN ESTERS .6. SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 3-(3-ISOXAZOLYL)OXYMETHYLCEPHALOSPORIN DERIVATIVES

The synthesis and biological activities of a series of 3-(isoxazol-3-yl)oxymethyl cephalosporins are described. 7-[2-(2-Aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-3-[ (isoxazol-3-yl)oxy-methyl]-3-cephem-4-carboxylic acid (7a) showed potent activity against both Gram-positive and Gram-negative bacteria including some β-lactamase producing species. Its pivaloyloxymethyl ester provided a good urinary recovery after oral administration to mice. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.