BCR/ABL AND SRC BUT NOT MYC AND RAS REPLACE V-ABL IN LYMPHOID TRANSFORMATION

Lymphoid cells transformed by temperature-sensitive Abelson virus die at the nonpermissive temperature. This property was exploited to show that bcr/abl and v-src but not myc and ras can replace the transforming signal of v-abl, a result suggesting that the former but not the latter oncogenes transform lymphoid cells via a similar pathway.