THE SYNTHESIS OF 2 2'-DEOXY CARBOCYCLIC PURINE NUCLEOSIDES LACKING THE 5'-METHYLENE

被引：24

作者：

KOGA, M ^{[1
]}

SCHNELLER, SW ^{[1
]}

机构：

[1] UNIV S FLORIDA,DEPT CHEM,TAMPA,FL 33620

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 41期

关键词：

D O I：

10.1016/S0040-4039(00)97979-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the adenine derivative (±)-(1α,2β,4α)-4-(6-amino-9H-purin-9-yl)-1,2-cyclopentanediol (2) and its hypoxanthine analogue (3) as carbocyclic nucleosides lacking the 5′-methylene is described in 7 steps from 3-cyclopenten-1-ylamine hydrochloride (4) in on overall yield of 30% for 2 and 27% for 3. © 1990.

引用

页码：5861 / 5864

页数：4

共 4 条

[1] A NEW ROUTE TO 1-SUBSTITUTED 3-CYCLOPENTENES [J].