ENHANCED INTESTINAL GLUCOSE AND ALANINE TRANSPORT IN CYSTIC-FIBROSIS

被引:61
作者
BAXTER, P
GOLDHILL, J
HARDCASTLE, J
HARDCASTLE, PT
TAYLOR, CJ
机构
[1] UNIV SHEFFIELD,DEPT BIOMED SCI,W BANK,SHEFFIELD S10 2TN,S YORKSHIRE,ENGLAND
[2] UNIV SHEFFIELD,DEPT PAEDIAT,SHEFFIELD S10 2TN,S YORKSHIRE,ENGLAND
关键词
D O I
10.1136/gut.31.7.817
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The rise in short-circuit current associated with the active transport of glucose and alanine was measured in intestinal biopsy samples from children with cystic fibrosis. The glucose-induced increase in the short-circuit current was greater in the cystic fibrosis tissues than in control samples over the whole range of concentrations tested (2.5-35 mM), a reflection of an increased maximum rate of transport. Similar results were obtained with alanine. These findings suggest that active Na+-linked nutrient transport is enhanced in cystic fibrosis.
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页码:817 / 820
页数:4
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