CDNA SEQUENCE OF XENOPUS-LAEVIS BONE MORPHOGENETIC PROTEIN-2 (BMP-2)

被引：22

作者：

PLESSOW, S ^{[1
]}

KOSTER, M ^{[1
]}

KNOCHEL, W ^{[1
]}

机构：

[1] UNIV ULM,BIOCHEM ABT,POB 4066,W-7900 ULM,GERMANY

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1089卷 / 02期

关键词：

BONE MORPHOGENETIC PROTEIN-2 (BMP-2); CDNA SEQUENCE; EVOLUTIONARY CONSERVATION; (X-LAEVIS);

D O I：

10.1016/0167-4781(91)90026-I

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Screening of a Xenopus laevis ovary cDNA library with an oligonucleotide derived from the activin A sequence led to the isolation of several clones belonging to the TGF-beta supergene family. One of these clones codes for the Xenopus bone morphogenetic protein 2 (BMP-2). The deduced protein contains 398 amino acids with a predicted M(r) of 45 581. Within the C-terminal 114 amino acids constituting the mature, biologically active protein there are only four exchanges (three of them are conservative ones) as compared to the corresponding human sequence.

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页码：280 / 282

页数：3

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