EFFECTS OF NOISE ON COCHLEAR POTENTIALS AND ENDOLYMPH POTASSIUM CONCENTRATION RECORDED WITH POTASSIUM-SELECTIVE ELECTRODES

被引:43
作者
SALT, AN
KONISHI, T
机构
[1] National Institute of Environmental Health Sciences, Research Triangle Park
关键词
cochlear potentials; endolymph; ion-electrodes; noise;
D O I
10.1016/0378-5955(79)90005-4
中图分类号
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号
100104 ; 100213 ;
摘要
Guinea pig cochleas were exposed to either broad-band noise at intensities between 95 and 115 dBA or octave-band noise centered at 380 Hz or 4.2 kHz at intensities between 115 and 125 dB SPL. Cochlear microphonics (CM), summating potentials (SP) and action potentials (AP) were recorded from differential electrodes in the perilymphatic scalae between successive 20-min periods of noise exposure. The endocochlear potential (EP) and endolymph potassium concentration [Kendo+] were recorded continuously from scala media using double-barreled potassium-sensitive electrodes. It was found that the initial exposure to noise at 115 dBA produced considerable supression of the CM and AP, while the EP and [Kendo+] were elevated above their normal values. When animals previously treated with kanamycin were subjected to the same level of noise exposure no systematic increase in either EP or [Kendo+] was observed. After prolonged exposure to 380 Hz octave-band noise at 125 dB SPL, a slow decline of EP and [Kendo+] was observed. The relationships between the changes in EP, [Kendo+] and CM are discussed. © 1979.
引用
收藏
页码:343 / 363
页数:21
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