KARYOTYPES IN 90 HUMAN GLIOMAS

被引：131

作者：

THIEL, G

LOSANOWA, T

KINTZEL, D

NISCH, G

MARTIN, H

VORPAHL, K

WITKOWSKI, R

机构：

[1] HUMBOLDT UNIV,BEREICH MED CHARITE,DEPT NEUROSURG,O-1040 BERLIN,GERMANY

[2] HUMBOLDT UNIV,BEREICH MED CHARITE,INST PATHOL,O-1040 BERLIN,GERMANY

[3] KLINIKUM BERLIN,NEUROSURG CLIN,BERLIN,GERMANY

[4] KLINIKUM BERLIN,INST PATHOL,BERLIN,GERMANY

来源：

CANCER GENETICS AND CYTOGENETICS | 1992年 / 58卷 / 02期

关键词：

D O I：

10.1016/0165-4608(92)90095-P

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytogenetic studies were performed on 90 human gliomas including 26 astrocytomas, 12 oligodendrogliomas, three oligo-astrocytomas, seven ependymomas, eight pilocytic astrocytomas, and 33 malignant gliomas (anaplastic astrocytomas and glioblastomas). The most common abnormalities were trisomy 7 in 23 cases, monosomy 22 in 15 cases, losses of the Y chromosome in 19 of 50 male cases, and losses of the X chromosome in 10 of 39 female cases. There are evident differences between the particular subgroups of gliomas. Monosomy 10 and double minutes are typical for malignant gliomas. The 58 determined chromosomal breakpoints were located on 45 different sites. Chromosomes 1, 9, 6, 3, 10, and 17 were predominantly involved.

引用

页码：109 / 120

页数：12

共 36 条

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