HIGHLY DIASTEREOSELECTIVE ADDITION OF METHYLLITHIUM TO CHIRAL ALPHA,BETA-DIALKOXY KETONES AND ITS APPLICATION TO THE STEREOCONTROLLED ASYMMETRIC-SYNTHESIS OF HIGHLY SUBSTITUTED TETRAHYDROFURANS

被引：11

作者：

CHIKASHITA, H

NAKAMURA, Y

UEMURA, H

ITOH, K

机构：

来源：

CHEMISTRY LETTERS | 1992年 / 03期

关键词：

D O I：

10.1246/cl.1992.439

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The nucleophilic addition of methyllithium to chiral alpha,beta-dialkoxy 1,3-dithian-2-yl ketones in ether gave the corresponding Cram type of anti isomers in excellent diastereoselectivity. The method was applied to the stereocontrolled synthesis of optically active and highly substituted tetrahydrofurans.

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页码：439 / 442

页数：4

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