IN-VIVO DEMONSTRATION OF FOCAL FIBRINOLYTIC-ACTIVITY IN ABDOMINAL AORTIC-ANEURYSMS

被引：30

作者：

TROMHOLT, N ^{[1
]}

JORGENSEN, SJ ^{[1
]}

HESSE, B ^{[1
]}

HANSEN, MS ^{[1
]}

机构：

[1] HILLEROD CTY HOSP,DEPT CLIN PHYSIOL,HILLEROD,DENMARK

来源：

EUROPEAN JOURNAL OF VASCULAR SURGERY | 1993年 / 7卷 / 06期

关键词：

AORTIC ANEURYSM; T-PA; COAGULOPATHY; RADIOLABELED ANTIBODY; SCINTIGRAPHY;

D O I：

10.1016/S0950-821X(05)80715-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Disseminated intravascular coagulation in association with arterial aneurysm has been reported in several cases. Reports have suggested a continuous deposition of fibrin and/or platelets at the site of the aneurysm followed by fibrinolysis as responsible for this disorder. To further investigate this theory we studied the in vivo binding of an indium-111-labelled monoclonal antibody against human tissue plasminogen activator (t-PA), a proteolytic enzyme involved in the fibrinolysis. Six patients admitted to the hospital for elective resection of an abdominal aortic aneurysm with a mural thrombus were examined. One day before the operation the antibody was injected intravenously. Scintigrams acquired just prior to operation and tissue samples obtained at the operation revealed an increased t-PA accumulation in the wall of the aneurysm. The study demonstrates in vivo, focally increased fibrinolysis activity in the aneurysm, explaining the coagulopathy observed in these patients. © 1993 Grune & Stratton Ltd.

引用

页码：675 / 679

页数：5

共 21 条

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