INTERFERON-ALPHA THERAPY DURING PREGNANCY IN CHRONIC MYELOGENOUS LEUKEMIA AND HAIRY-CELL LEUKEMIA

被引：89

作者：

BAER, MR

OZER, H

FOON, KA

机构：

[1] UNIV N CAROLINA,DIV MED ONCOL,CHAPEL HILL,NC 27514

[2] UNIV N CAROLINA,LINEBERGER COMPREHENS CANC RES CTR,CHAPEL HILL,NC 27514

[3] SCRIPPS CLIN & RES FDN,IDA M & CECIL H GREEN CTR,LA JOLLA,CA 92037

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1992年 / 81卷 / 02期

关键词：

D O I：

10.1111/j.1365-2141.1992.tb08202.x

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Interferon-alpha is an effective agent in the treatment of chronic myelogenous leukaemia and hairy cell leukaemia. Because interferon-alpha does not inhibit DNA synthesis, we have used it to treat these diseases during pregnancy. We report here two patients with chronic myelogenous leukaemia and two patients with hairy cell leukaemia managed with interferon-alpha during pregnancy. Interferon-alpha was well tolerated, and the pregnancies proceeded without complications. All four infants were apparently normal at birth, and all four have enjoyed normal growth and development. Interferon-alpha may represent relatively safe therapy during pregnancy, because of its lack of inhibition of DNA synthesis. Nevertheless, recommendations regarding the use of interferon-alpha to treat chronic leukaemias during pregnancy must await further experience with this agent in this setting.

引用

页码：167 / 169

页数：3

共 11 条

[1]

NORMAL FULL-TERM PREGNANCY IN A PATIENT WITH CHRONIC MYELOGENOUS LEUKEMIA TREATED WITH ALPHA-INTERFERON [J].