COMPARISON BETWEEN DIPLOID AND ANEUPLOID HEPATOCELLULAR CARCINOMAS - A FLOW CYTOMETRIC STUDY

被引:35
作者
NAGASUE, N
YAMANOI, A
TAKEMOTO, Y
KIMOTO, T
UCHIDA, M
CHANG, YC
TANIURA, H
KOHNO, H
NAKAMURA, T
机构
[1] Second Department of Surgery, Shimane Medical University, Izumo
关键词
D O I
10.1002/bjs.1800790723
中图分类号
R61 [外科手术学];
学科分类号
摘要
Nuclear DNA content of hepatocellular carcinoma (HCC) was estimated by flow cytometry after hepatic resection in 91 patients during the past 5 years. There were 53 diploid and 38 aneuploid tumours. Clinicopathological features were compared retrospectively between the patients with diploid and those with aneuploid HCC. DNA ploidy did not show any correlation with age, sex, alcohol abuse, hepatitis B virus, serum alpha-fetoprotein level or underlying liver disease. Histopathologically, the incidence of HCC < 2 cm in diameter tended to be higher in the diploid group but no difference was seen for large tumours (> 5 cm). The grade of tumour differentiation also tended to be higher in this group of small HCC. The ploidy pattern did not influence the rate of capsule or daughter nodule formation, or venous invasion. There were no significant differences in survival rate or in the incidence and time of intrahepatic tumour recurrence between the two groups. This study may indicate that nuclear DNA ploidy is not a particularly predictive factor for the surgical treatment of HCC.
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页码:667 / 670
页数:4
相关论文
共 25 条
[1]   MORPHOLOGY OF CIRRHOSIS [J].
ANTHONY, PP ;
ISHAK, KG ;
NAYAK, NC ;
POULSEN, HE ;
SCHEUER, PJ ;
SOBIN, LH .
JOURNAL OF CLINICAL PATHOLOGY, 1978, 31 (05) :395-414
[2]   INTRAHEPATIC RECURRENCE AFTER RESECTION OF HEPATOCELLULAR-CARCINOMA COMPLICATING CIRRHOSIS [J].
BELGHITI, J ;
PANIS, Y ;
FARGES, O ;
BENHAMOU, JP ;
FEKETE, F .
ANNALS OF SURGERY, 1991, 214 (02) :114-117
[3]  
CHEN MF, 1991, SURGERY, V109, P455
[4]   CLONAL ORIGIN OF RECURRENT HEPATOCELLULAR CARCINOMAS [J].
CHEN, PJ ;
CHEN, DS ;
LAI, MY ;
CHANG, MH ;
HUANG, GT ;
YANG, PM ;
SHEU, JC ;
LEE, SC ;
HSU, HC ;
SUNG, JL .
GASTROENTEROLOGY, 1989, 96 (02) :527-529
[5]  
Child CG, 1964, MAJOR PROBLEMS CLIN, V1, P1
[6]  
Couinaud C, 1957, FOIE ETUDES ANATOMIQ
[7]  
EDMONDSON HA, 1954, CANCER-AM CANCER SOC, V7, P462, DOI 10.1002/1097-0142(195405)7:3<462::AID-CNCR2820070308>3.0.CO
[8]  
2-E
[9]  
ESUMI M, 1986, CANCER RES, V46, P5767
[10]  
EZAKI T, 1988, CANCER, V61, P106, DOI 10.1002/1097-0142(19880101)61:1<106::AID-CNCR2820610118>3.0.CO