SYNTHESIS OF 2-THIOHYDANTOIN DERIVATIVES WITH POTENTIAL IMMUNOMODULATING AND ANTICANCER ACTIVITIES

被引：15

作者：

BLANC, M ^{[1
]}

CUSSAC, M ^{[1
]}

BOUCHERLE, A ^{[1
]}

LECLERC, G ^{[1
]}

机构：

[1] FAC PHARM LA TRONCHE,PHARMACOCHIM MOLEC GRP,CHIM THERAPEUT LAB,F-38700 LA TRONCHE,FRANCE

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 27卷 / 03期

关键词：

2-THIOHYDANTOINS; IMMUNOMODULATORS; ANTICANCER AGENTS;

D O I：

10.1016/0223-5234(92)90011-O

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Functionallized 2-thiohydantoins were synthesized. Their immunomodulating and anticancer actions were evaluated. It is shown that for these potentially active products on chronic inflammatory diseases involving cellular-mediated immunity the development of immunomodulating activity is related to the cyclised thiourea structure. Anticancer activity is weak. These biological activities are however insufficient to promote an industrial development.

引用

页码：267 / 275

页数：9

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