SYMPHYTOXIDE-A, A TRITERPENOID SAPONIN FROM THE ROOTS OF SYMPHYTUM-OFFICINALE

被引：16

作者：

AHMAD, VU

NOORWALA, M

MOHAMMAD, FV

SENER, B

GILANI, AUH

AFTAB, K

机构：

[1] GAZI UNIV,FAC PHARM,DEPT PHARMACOGNOSY,ANKARA,TURKEY

[2] AGA KHAN UNIV,COLL MED,DEPT PHARMACOL,KARACHI 74800,PAKISTAN

来源：

PHYTOCHEMISTRY | 1993年 / 32卷 / 04期

关键词：

SYMPHYTUM-OFFICINALE; BORAGINACEAE; ROOTS; TRITERPENOID SAPONIN; SYMPHYTOXIDE-A; HEDERAGENIN; HYPOTENSIVE;

D O I：

10.1016/0031-9422(93)85244-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new triterpenoidal saponin of hederagenin named symphytoxide A has been isolated from the ethanolic extract of the roots of Symphytum officinale and characterized on the basis of chemical investigations and spectroscopic studies as 3-O-[beta-D-glucopyranosyl-(1 --> 2)-beta-D-glucopyranosyl-(1 --> 4)-alpha-L-arabinopyranosyl] hederagenin. The structure of this new saponin was established on the basis of ID and 2D NMR experiments including heteroCOSY, COSY-45-degrees as well as HMBC measurements and other spectroscopic techniques. The saponin exhibited hypotensive activity in anaesthetized rats.

引用

页码：1003 / 1006

页数：4

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