QUANTIFICATION OF PHTHALOCYANINE CONCENTRATION IN RAT-TISSUE USING LASER-INDUCED FLUORESCENCE SPECTROSCOPY

被引：25

作者：

PANJEHPOUR, M ^{[1
]}

SNEED, RE ^{[1
]}

FRAZIER, DL ^{[1
]}

BARNHILL, MA ^{[1
]}

OBRIEN, SF ^{[1
]}

HARB, W ^{[1
]}

OVERHOLT, BF ^{[1
]}

机构：

[1] UNIV TENNESSEE,COLL VET MED,KNOXVILLE,TN 37901

来源：

LASERS IN SURGERY AND MEDICINE | 1993年 / 13卷 / 01期

关键词：

PHOTODYNAMIC THERAPY; PHOTOSENSITIZER; INVIVO ESTIMATION;

D O I：

10.1002/lsm.1900130107

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Quantification of photosensitizer concentration in tissue should improve planning and outcome of photodynamic therapy. Laser-induced fluorescence (LIF) can be used to measure in vivo fluorescence of photosensitizers in tissue. This study was designed to determine if in vivo fluorescence intensity of chloroaluminum phthalocyanine tetrasulfonate correlates with its concentration in different rat tissues. Following LIF measurements, the animals were humanely euthanized and the concentration of phthalocyanine in different tissues was determined using chemical extraction technique. The correlation of phthalocyanine fluorescence intensity and its concentration was determined for each tissue using Pearson product-moment correlation analysis. A strong correlation between in vivo phthalocyanine fluorescence intensity and its concentration was found for spleen, kidney, liver, and chemically induced mammary adenocarcinoma. Low correlation was found for thigh skin and planum of nose. No correlation was found for thigh muscle and tongue.

引用

页码：23 / 30

页数：8

共 11 条

[1] BENSON RC, 1982, MAYO CLIN PROC, V57, P548
[2] PHOTODYNAMIC THERAPY WITH PORPHYRIN AND PHTHALOCYANINE SENSITIZATION - QUANTITATIVE STUDIES IN NORMAL RAT-LIVER
BOWN, SG
TRALAU, CJ
SMITH, PDC
AKDEMIR, D
WIEMAN, TJ
[J]. BRITISH JOURNAL OF CANCER, 1986, 54 (01) : 43 - 52
[3] DOIRON DR, 1979, CHEST, V76, P27, DOI 10.1378/chest.76.1.27
[4] PHOTODYNAMIC THERAPY - NEW APPROACHES
DOUGHERTY, TJ
[J]. SEMINARS IN SURGICAL ONCOLOGY, 1989, 5 (01): : 6 - 16
[5] HUGGINS CB, 1987, J LAB CLIN MED, V109, P262
[6] KING EG, 1982, CANCER, V49, P777, DOI 10.1002/1097-0142(19820215)49:4<777::AID-CNCR2820490429>3.0.CO
[7] 2-5
[8] PHOTODYNAMIC THERAPY
MANYAK, MJ
RUSSO, A
SMITH, PD
GLATSTEIN, E
[J]. JOURNAL OF CLINICAL ONCOLOGY, 1988, 6 (02) : 380 - 391
[9] PROFIO AE, 1990, PHOTODYNAMIC THERAPY, V1, P77
[10] PHOTODYNAMIC THERAPY WITH PHTHALOCYANINE SENSITIZATION - QUANTITATIVE STUDIES IN A TRANSPLANTABLE RAT FIBROSARCOMA
TRALAU, CJ
MACROBERT, AJ
COLERIDGESMITH, PD
BARR, H
BOWN, SG
[J]. BRITISH JOURNAL OF CANCER, 1987, 55 (04) : 389 - 395

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