ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONATE AND KAINATE DIFFERENTLY AFFECT NEURONAL CYTOARCHITECTURE OF RAT CEREBELLAR GRANULE CELLS

被引：11

作者：

PIZZI, M

FALLACARA, C

CONSOLANDI, O

MEMO, M

SPANO, PF

机构：

来源：

NEUROSCIENCE LETTERS | 1994年 / 166卷 / 01期

关键词：

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONATE; KAINATE; N-METHYL-D-ASPARTATE; CEREBELLAR GRANULE CELL; DEVELOPMENT;

D O I：

10.1016/0304-3940(94)90844-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rat cerebellar granule cells cultured in media containing 12 mM KCI showed short life-span, did not branch, and died after 10 days in vitro. The cell exposure to N-methyl-D-aspartate (NMDA) or to kainate promoted both neuron survival and branching, reproducing the viability and the neurite extension routinely observed in cultures maintained in media containing 25 mM KCl. Exposure of neurons to alpha-amino3-hydroxy5-methyl-4- isoxazolepropionate (AMPA) resulted in an increased survival not associated with neuritic arborization. These results suggest that the glutamate ionotropic receptor subtypes differently contribute in elaborating neuronal morphogenesis.

引用

页码：77 / 80

页数：4

共 28 条

[1]

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[2] N-METHYL-D-ASPARTATE PROMOTES THE SURVIVAL OF CEREBELLAR GRANULE CELLS IN CULTURE [J].