MEDIAN EMINENCE-AFFERENT VASOACTIVE-INTESTINAL-PEPTIDE (VIP) NEURONS IN THE HYPOTHALAMUS - LOCALIZATION BY SIMULTANEOUS TRACT TRACING AND IMMUNOCYTOCHEMISTRY

被引：14

作者：

DALCIK, H ^{[1
]}

PHELPS, CJ ^{[1
]}

机构：

[1] TULANE UNIV,DEPT ANAT,1430 TULANE AVE,NEW ORLEANS,LA 70112

来源：

PEPTIDES | 1993年 / 14卷 / 05期

关键词：

VASOACTIVE INTESTINAL PEPTIDE; RETROGRADE TRACT TRACING; PARAVENTRICULAR NUCLEUS; MEDIAN EMINENCE; HYPOTHALAMUS;

D O I：

10.1016/0196-9781(93)90087-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Retrograde tract tracing and immunocytochemistry were used to investigate the CNS source of the VIP that is present in high concentrations in the hypophysial portal blood and has been shown to have a stimulatory effect on pituitary prolactin secretion. Fluoro-gold (FG), which enters the CNS through areas devoid of the blood-brain barrier, such as median eminence, was injected peripherally. Brain sections from FG-treated animals were immunostained for VIP. A small population of VIP-containing cell bodies in the parvocellular and periventricular parts of the paraventricular nucleus (PVN) was also labeled with FG. Vasoactive intestinal peptide-immunoreactive perikarya not labeled with FG were also observed in the PVN, as well as FG-labeled cells that did not contain VIP. The results suggest that some VIP-producing neurons in the PVN project to the median eminence and are, therefore, functionally related to pituitary regulation; the function of other VIP neurons in the PVN is unknown.

引用

页码：1059 / 1066

页数：8

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