CHEMOATTRACTION OF HUMAN BLOOD T-LYMPHOCYTES BY INTERLEUKIN-15

被引：229

作者：

WILKINSON, PC

LIEW, FY

机构：

[1] Department of Immunology, University of Glasgow, Western Infirmary, Glasgow

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1995年 / 181卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1084/jem.181.3.1255

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recombinant interleukin (IL)-15, derived from a simian kidney epithelial cell line, is a chemoattractant for human blood T lymphocytes judged by its ability to increase the proportion of cells in polarized morphology, to stimulate invasion of collagen gels containing IL-15, and to increase the proportion of locomotor cells observed by time-lapse videorecording. The ability of lymphocytes to respond was partly, but not completely, inhibited by pretreatment with anti-IL-2 receptor beta-chain. The activity of IL-15 was completely abolished by preincubation with aIL-15 but unaffected by preincubation with aIL-2. No response of monocytes, neutrophils, or B lymphocytes to IL-15 was observed.

引用

页码：1255 / 1259

页数：5

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