CYTOCHROME P-420 - TUBULAR AGGREGATES FROM HEPATIC MICROSOMES

被引：18

作者：

SHOEMAN, DW

WHITE, JG

MANNERING, GJ

机构：

[1] Department of Pharmacology, College of Medical Sciences, University of Minnesota, Minneapolis

来源：

SCIENCE | 1969年 / 165卷 / 3900期

关键词：

D O I：

10.1126/science.165.3900.1371

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Aggregates were formed when clear supernatants from hepatic microsomes that had been treated with steapsin were desalted and concentrated. These aggregates contain large numbers of uniform tubular elements. These structures resemble microtubules seen in many cells but differ in their substructure. The aggregates were rich in cytochrome P-420. Unlike soluble cytochrome P-420, the cytochrome P-420 contained in the aggregates combines with drugs to give the characteristic difference spectra normally seen only with cytochrome P-450 contained in intact microsomes.

引用

页码：1371 / +

页数：1

共 16 条

[1]

HARDING BW, 1966, J BIOL CHEM, V241, P2212

[2] SUBSTRATE INTERACTION WITH HYDROXYLASE SYSTEM IN LIVER MICROSOMES [J].